Pascal Michon (FMHS Research Coordinator)

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Associate Professor and FMHS Research Coordinator
Post Graduate & Research Center
Pascal Michon(PhD)
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
Tel: (+675) 422 2937
EXT: 806
Tel: (direct) (+675) 422 2937

 


 

QUALIFICATIONS
• Master of Science in Parasitology: Ecology and Pathology (1987) University of Montpellier France
• PhD in Molecular Parasitology (2001), University of Notre Dame, USA


TEACHING
In general:

  • • Biological Sciences
  • • Parasitology, Infectious Diseases
  • • Research

 

At DWU:

  • • HE126 Principles of Medical Biochemistry
  • • HE324 Health Research Project
  • • RM606 Ethics in Research (Master of Research Methodology)
  • • HE321 Epidemiology of common diseases in PNG (malaria, as guest lecturer)
  • • HE215 Infestious Diseases & Lifestyle Diseases (malaria, as guest lecturer)
  • • PY110 Basic Medical Sciences (Microbiology)

 

EXPERIENCE
• Teaching Assistant in General Biology, Cellular Biology and Parasitology, Department of Biological Sciences, University of Notre Dame, USA (1995- 2000)
• Postdoctoral Research Fellow, The Peter Medawar Building for Pathogen Research / Department of Zoology, University of Oxford, UK (2001-2004)
• Senior Research Fellow, Head of the Molecular Parasitology Section, PNG Institute of Medical Research, Madang, Papua New Guinea (2004- 2010)
• Dean of Health Science, Divine Word University, Madang, Papua New Guinea (2010- 2014)
• Research Coordinator, Faculty of Medicine & Health Sciences [FMHS] (2015 - present)

 

PROFESSIONAL ASSOCIATIONS
• The American Society of Tropical Medicine & Hygiene (1995-2001 & 2006)
• The British Society of Parasitology (2001-2004)
• The Medical Society of Papua New Guinea (2004-present)

 

RESEARCH
Infectious Diseases / Molecular Parasitology / Genetics & Molecular Epidemiology of malaria / Nutrition / Lifestyle and non-communicable diseases

WEBLINKS
LinkedIn:  https://www.linkedin.com/profile/view?id=AAMAAAMVFncBYkAbFXrR0b45qYQcG2S3ywnvnPY&trk=hp-identity-name

ResearchGate:  https://www.researchgate.net/profile/Pascal_Michon

 

SELECTED PUBLICATIONS

Campino, S., Auburn, S., Kivinen, K., Zongo, I., Ouedraogo, J. B., Mangano, V., Michon, P., Kwiatkowski, D. P. (2011). Population genetic analysis of Plasmodium falciparum parasites using a customized Illumina GoldenGate genotyping assay. [Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't]. PloS one, 6(6), e20251. doi: 10.1371/journal.pone.0020251


Cole-Tobian, J. L., Michon, P., Dabod, E., Mueller, I., & King, C. L. (2007). Dynamics of asymptomatic Plasmodium vivax infections and Duffy binding protein polymorphisms in relation to parasitemia levels in Papua New Guinean children. American Journal of Tropical Medicine and Hygiene, 77(5), 955-962.

D'Ombrain, M. C., Robinson, L. J., Stanisic, D. I., Taraika, J., Bernard, N., Michon, P., Schofield, L. (2008). Association of early interferon-gamma production with immunity to clinical malaria: a longitudinal study among Papua New Guinean children. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.]. Clin Infect Dis, 47(11), 1380-1387. doi: 10.1086/592971.

DaRe, J. T., Mehlotra, R. K., Michon, P., Mueller, I., Reeder, J., Sharma, Y. D.,  Zimmerman, P. A. (2007). Microsatellite polymorphism within pfcrt provides evidence of continuing evolution of chloroquine-resistant alleles in Papua New Guinea. Malar J, 6, 34.

Fowkes, F. J., Michon, P., Pilling, L., Ripley, R. M., Tavul, L., Imrie, H. J., Day, K. P. (2008). Host erythrocyte polymorphisms and exposure to Plasmodium falciparum in Papua New Guinea. Malar J, 7, 1.

Jallow, M., Teo, Y. Y., Small, K. S., Rockett, K. A., Deloukas, P., Clark, T. G., ... Michon, P., ... Kwiatkowski, D. P. (2009). Genome-wide and fine-resolution association analysis of malaria in West Africa. [Research Support, Non-U.S. Gov't]. Nat Genet, 41(6), 657-665. doi: 10.1038/ng.388.

King C.L., Michon P., Shakri A.R., Marcotty A., Stanisic D., Cole-Tobian J. L., Shakri R., Mueller I., and Chitnis C.E. (2008) Naturally Acquired Blocking Antibodies against the Receptor-Binding Domain of Duffy Binding Protein are Associated with Protection against Plasmodium vivax Infection.  Proceedings of the National Academy of Sciences U S A. 105(24): 8363-8.

Lin, E., Tavul, L., Michon, P., Richards, J. S., Dabod, E., Beeson, J. G., . . . Mueller, I. (2010). Minimal association of common red blood cell polymorphisms with Plasmodium falciparum infection and uncomplicated malaria in Papua New Guinean school children. [Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.]. Am J Trop Med Hyg, 83(4), 828-833. doi: 10.4269/ajtmh.2010.09-0713.

Manning, L., Laman, M., Law, I., Bona, C., Aipit, S., Teine, D., Michon, P., Davis, T. M. (2011). Features and prognosis of severe malaria caused by Plasmodium falciparum, Plasmodium vivax and mixed Plasmodium species in Papua New Guinean children. [Research Support, Non-U.S. Gov't]. PloS One, 6(12), e29203. doi: 10.1371/journal.pone.0029203.

Manning L., Laman M., Rosanas-Urgell A., Michon P., Aipit S., Bona C., Siba P., Mueller I., Davis T.M. (2012) Severe anemia in Papua New Guinean children from a malaria-endemic area: a case-control etiologic study. PLoS Negl Trop Dis. 6(12): e1972. doi: 10.1371/journal.pntd.0001972.  Epub 2012 Dec 13.

Manning, L., Cutts J.*, Stanisic D.I.*, Laman, M., Carmagnac, A.,  Allen, S., O’Donnell, A., Karunajeewa, H., Rosanas-Urgell, A., Siba,, P., Davis T.M.E., Michon, P., Schofield, L., Rockett, K.,  Kwiatkowski, D., and Mueller, I. (2015) A Toll like receptor-1 variant and its characteristic cellular phenotype is associated with severe malaria in Papua New Guinea children. Genes and Immunity doi: 10.1038/gene.2015.50.

Manske, M., Miotto, O., Campino, S., Auburn, S., Almagro-Garcia, J., Maslen, G., Michon, P., Kwiatkowski, D. P. (2012). Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing. [Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't]. Nature, 487(7407), 375-379. doi: 10.1038/nature11174.

Michon, P., Cole-Tobian, J. L., Dabod, E., Schoepflin, S., Igu, J., Susapu, M., Mueller, I. (2007). The risk of malarial infections and disease in Papua New Guinean children. Am J Trop Med Hyg, 76(6), 997-1008.

Michon, P., Fraser, T., & Adams, J. H. (2000). Naturally acquired and vaccine-elicited antibodies block erythrocyte cytoadherence of the Plasmodium vivax Duffy binding protein. Infect Immun, 68(6), 3164-3171.

Michon, P., Stevens, J. R., Kaneko, O., & Adams, J. H. (2002). Evolutionary relationships of conserved cysteine-rich motifs in adhesive molecules of malaria parasites. Mol Biol Evol, 19(7), 1128-1142.

Michon, P., Woolley, I., Wood, E. M., Kastens, W., Zimmerman, P. A., & Adams, J. H. (2001). Duffy-null promoter heterozygosity reduces DARC expression and abrogates adhesion of the P. vivax ligand required for blood-stage infection. FEBS Lett, 495(1-2), 111-114.

Michon, P. A., Arevalo-Herrera, M., Fraser, T., Herrera, S., & Adams, J. H. (1998). Serologic responses to recombinant Plasmodium vivax Duffy binding protein in a Colombian village. Am J Trop Med Hyg, 59(4), 597-599.

Preston, M.D., Assefa, S., Ocholla, H., Sutherland, C., Borrmann, S., Nzila, A., Michon P., Tinh Hien, T., Bousema, T., Drakeley, C., Zongo, I., Ouedraogo, J-B., Djimde, A., Doumbo, O., Nosten, F., Fairhurst, R., Conway, D., Roper, C. and Clark, T.G. (2014)  PlasmoView: A web-based resource to visualise global malaria genomic variation. Journal of Infectious Diseases 209(11):1808-15.


Preston, M.D., Campino, S., Assefa, SA, Echeverry, DF, Ocholla, H, Amambua-Ngwa, A, Stewart LB, Conway, DJ, Borrmann, S, Michon, P, Zongo, I, Ouédraogo, J.B., Djimde, A.A., Doumbo, O.K., Nosten, F., Pain, A., Bousema, T., Drakeley, C.J., Fairhurst, R.M., Sutherland, C.J., Roper C., Clark, T.G. (2014). A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains. Nature Communications, 5, 4052.

Reiling, L., Richards, J. S., Fowkes, F. J., Wilson, D. W., Chokejindachai, W., Barry, A. E., Michon, P., Beeson, J. G. (2012). The Plasmodium falciparum erythrocyte invasion ligand Pfrh4 as a target of functional and protective human antibodies against malaria. [Research Support, Non-U.S. Gov't]. PloS one, 7(9), e45253. doi: 10.1371/journal.pone.0045253.

Rosanas-Urgell, A., Lin, E., Manning, L., Rarau, P., Laman, M., Senn, N., Michon, P.,Mueller, I. (2012). Reduced risk of Plasmodium vivax malaria in Papua New Guinean children with Southeast Asian ovalocytosis in two cohorts and a case-control study. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.]. PLoS Med, 9(9), e1001305. doi: 10.1371/journal.pmed.1001305.

Rosanas-Urgell, A., Senn, N., Rarau, P., Aponte, J. J., Reeder, J. C., Siba, P. M., Michon, P., Mueller, I. (2012). Lack of associations of alpha(+)-thalassemia with the risk of Plasmodium falciparum and Plasmodium vivax infection and disease in a cohort of children aged 3-21 months from Papua New Guinea. Int J Parasitol, 42(12), 1107-1113. doi: 10.1016/j.ijpara.2012.10.001.

Sereno, D., Michon, P., Brajon, N., & Lemesre, J. L. (1997). Phenotypic characterization of Leishmania mexicana pentamidine-resistant promastigotes. Modulation of the resistance during in-vitro developmental life cycle. Comptes Rendus de l’Academie des Sciences III, 320(12), 981-987.

Sutherland, C. J., Tanomsing, N., Nolder, D., Oguike, M., Jennison, C., Pukrittayakamee, S., Michon, P., Polley, S. D. (2010). Two nonrecombining sympatric forms of the human malaria parasite Plasmodium ovale occur globally. [Research Support, Non-U.S. Gov't]. J Infect Dis, 201(10), 1544-1550. doi: 10.1086/652240.

Tanomsing, N., Imwong, M., Pukrittayakamee, S., Chotivanich, K., Looareesuwan, S., Mayxay, M., Michon, P., Day, N. P. (2007). Genetic analysis of the dihydrofolate reductase-thymidylate synthase gene from geographically diverse isolates of Plasmodium malariae. [Research Support, Non-U.S. Gov't]. Antimicrob Agents Chemother, 51(10), 3523-3530. doi: 10.1128/AAC.00234-07.

Tavul, L., Mueller, I., Rare, L., Lin, E., Zimmerman, P. A., Reeder, J., Michon, P. (2008). Glycophorin C delta(exon3) is not associated with protection against severe anaemia in Papua New Guinea. [Research Support, U.S. Gov't, Non-P.H.S.]. P N G Med J, 51(3-4), 149-154.

The Malaria Genomic Epidemiology Network (2008) A global network for investigating the genomic epidemiology of malaria Nature 456 (7223): 732-7

The Malaria Genomic Epidemiology Network ¶ (2014). Reappraisal of known malaria resistance loci in a large multicenter study. Nature Genetics 46(11):1197-204

Wildig, J.*, Michon, P.*, Siba, P., Mellombo, M., Ura, A., Mueller, I., & Cossart, Y. (2006). Parvovirus B19 infection contributes to severe anemia in young children in Papua New Guinea. J Infect Dis, 194(2), 146-153.

Consortium
* Joint First Authorship